Researchers from the University of Minho in Portugal have discovered that rats exposed before birth to glucocorticoids (GC) not only show several brain abnormalities similar to those found in addicts, but become themselves susceptible to addiction (the glucorticoids, which are stress hormones, were used to mimic pre-natal stress).  But even more remarkable, Ana João Rodrigues, Nuno Sousa and colleagues were able to reverse all the abnormalities  (including the addictive behavior) by giving the animals dopamine (a neurotransmitter/ brain chemical).  The study has several implications – for a start it alerts for the dangers of high levels of stress during pregnancy, but - since GC are often prescribed as an anti-inflammatory or to help organ maturation during pregnancy - it also calls for an urgent investigation on the effects of this drug in pregnant women. But it is what we learn about addiction that is most interesting - the work not only unveils stress as a new susceptibility factor for the disease, but  also a very simple treatment that, if translated into humans, could one day mean an effective treatment, and maybe even the prevention of human addiction.  Drug addiction was for a long time a character flaw, a moral problem. Now, instead,  is accepted as the complex brain disease that is with the addict a patient in need of treatment. After all many people try drugs, but only a few become addicts And it is in these few that lays the key to the disease and its treatment. So what do we know about these patients and the disease? First although the psychological and social contexts in which the drug is taken are important,  as much as 50% of the compulsion is in the  individual’s genetic makeup. We know that addiction is linked to the mesolimbic system - the brain area that evolved to provide feelings of pleasure to actions that increase our survival chances, such as eat, sex and social stimulation. In fact, drugs activate the mesolimbic circuit too, only far stronger than any physiologic stimulus.  This leads to the production of very high quantities of dopamine – the brain chemical linked to pleasure – creating the euphoria that brings users back. After while, though, the brain no longer can cope with the constant ” high” and adapts by becoming desensitised to dopamine (produced by any type of stimulus) what leads users to consume more in order to “feel” again and trapping those more susceptible in addiction. And with the brain changes induced by drugs being apparently long-lasting - since both cravings and relapses don’t disappear with time – it is not easy to escape once trapped. Adding another piece to the puzzle, recently the disease was also linked to stress during crucial developmental periods, such as feotal life. In fact, high levels of prenatal stress increase propensity to mental problems and now have been suggested also to substance abuse, with the effects being mediated by glucocorticoids (GC).    Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 Rodrigues and Sousa’s group have a long history of interest in stress and have seen before that  rats from mothers injected with GC while pregnant (mimicking pre-natal stress) show changes in their mesolimbic area and in the dopamine response. So in the study now published, following these results and the addiction-stress link, the researchers investigated the responses to drugs in rats exposed to GC while in the uterus. These rats were found to have a susceptibility to addiction not present in control (non-exposed) rats. When their mesolimbic system was examined they also showed several structural and molecular abnormalities,  including less dopamine. The levels of their dopamine receptor Drd2, despite initially being very high, once they experimented drugs, went to abnormally low levels . So why is this important? Because reduced dopamine and Drd2 levels are typical of addicts suggesting that stress and long-term exposure to drugs affect the brain in very similar ways what could explain why the first could lead to the second.  Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 The good news is that low levels of dopamine can be treated so Rodrigues and colleagues restored the rats’ dopamine levels to normal just to find,much to their surprise, that all the structural and molecular abnormalities induced by prenatal GC were reversed. Even more surprising, the addictive behavior also disappeared. Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 As Ana João Rodrigues explains, “This is a remarkable result because it suggests that with a relatively simple pharmacological approach- restoration of dopamine levels- we can eventually treat, and even more importantly, potentially prevent drug abuse in vulnerable individuals. Of course that we still have a long way to go but our results are quite promising. In fact, if we know where susceptibility to substance abuse lies – and low dopamine and altered Drd2 response seems to be it - then maybe we can find better ways to prevent/treat this disorder. “ Restoring dopamine levels has been used to treat cocaine cravings but the few trials looking at its effect on addiction were never very clear. One possible reason might be the length or the dosages used – in Rodrigues’ study, rats treated for 3 days reverted back to an addictive behavior 3 weeks after the end of the treatment,  but this no longer occurs if the treatment continues for 3 weeks Now it will be necessary to test this new theory in humans what could be problematic with addicts as they are notoriously not the most cooperative or reliable research subjects. Large human studies on the effect of prenatal stress are also difficult to mount but there are a couple of them being run at the moment that could be tagged into such as “Project Ice Storm” in Canada.This study is following women pregnant n January 98 in southern Québec during an extreme ice storm that led to electrical power failures affecting more than 3 million people for as much as 6 weeks during the coldest month of the year(when temperatures can go to -18 C).  It is still early for any studies on addiction(the children are only 13 years old after all) but it will be an interesting place to look, especially since abnormal levels of behavioral and cognitive problems have already been detected by scientists. Drug abuse and addiction carry enormous social and financial costs to society, families and individuals.Only in the US, the National Institute for Drug Abuse calculates that more than600 billion dollars are being spent, annually, to combat the disease. Despite this,a steady increase of drug use among teenagers and in prescription drugs continues with treatments remaining as inefficient as ever.  Rodrigues and Sousa’s work might be the first step towards a solution if their remarkable results can be translated into humans.

The jury hear evidence that MJ had also taken a large number of sleeping pills… 08:42, Sunday, 30 October 2011 The last defence witness in the trial of Dr Conrad Murray, Michael Jackson’s personal physician, has told the courtroom that he believed the star was responsible for his own death.   Dr Paul White told jurors that the most likely cause of death was self-injection of a fatal dose of the anesthetic Propofol, after Murray had already administered a small amount. "With the administration of the additional 25 milligrams that we're speculating was self-injected by Mr Jackson, the level increases rapidly and at the time of death would be almost identical to the level found in the urine at autopsy," Dr White said. He revealed that the superstar also appeared to have taken a large dose of sedatives – eight Lorazepam tablets – earlier in the night without Murray’s knowledge. White said that mixing the two drugs would be deadly. "The combination effect is potentially profound." Earlier this week a specialist testified that Michael may have also been addicted to the painkiller Demerol, and was also a regular user of Botox. Murray is charged with involuntary manslaughter into the star’s untimely death in June 2009. The prosecution has already presented four weeks of evidence so it won’t be long before the jurors retire to decide the verdict. Michael’s sister Janet Jackson recently postponed tour dates in Australia in order to be in LA when the verdict is announced. She explained her decision in a statement: "When I planned these shows, the schedule in California was completely different. After talking with my family last night, I decided we must be together right now.”

Montgomery County doctor and his son surrendered to police Thursday morning after investigators discovered that they were supplying known drug addicts with large supplies of narcotics, according to authorities. At least one person died of an overdose on Dr. Richard Ruth's drugs, police say. Ruth, of Souderton, was performing insincere medical exams for drug seekers and then providing them with prescription drugs that often ended up being sold in large quantities on the street, police say. Ruth has been running this drug operation for years, authorities say. The lengthy police investigation into Ruth's alleged crimes was called "Operation Pill Pusher." "We know that this community has been plagued by prescription drug abuse and overdoses and this was the go-to guy in the community," said District Attorney Risa Vetri Ferman. Ruth’s son, Michael Ruth, was his medical assistant. "For them to come in and say he’s unlawfully doing things is just an atrocity," a teary-eyed Michael told NBC Philadelphia’s Denise Nakano. Michael also faces charges in the drug scheme that involved charging patients for the narcotic prescriptions and insurance companies for the bogus office visits, police say. Police were tipped off to Dr. Ruth’s drug dealing scheme when sources told them last September that they were able to obtain large amounts of oxycodone from the doctor. In addition to providing drugs to people who dealt them on the street, Dr. Ruth ignored pleas from family members of the drug-addicted patients who asked him to stop prescribing drugs like Percocet and Oxycodone, police say. Dr. Ruth was charged with more than 40 counts of fraud, knowingly prescribing to drug addicts, prescription fraud, and conspiracy, among others. His son Michael was charged with similar crimes.

LOST SOUL: Amy Winehouse in London on July 23, 2009, exactly two years before her death. (Photo by Shaun Curry/Newscom.)

This week, Amy Winehouse’s official cause of death was finally announced, three months after the singer was discovered dead in her London home on July 23. After initial autopsy results came back inconclusive, the coroner determined that Winehouse died from consuming an extreme amount of alcohol. According to test results, the 27-year-old singer’s blood alcohol level was five times the drunk-driving limit. Her doctor said the troubled star had resumed drinking in the days prior to her death, after a short-lived period of sobriety.

Besides being a talented artist, Winehouse was emblematic of the numerous celebrities today whose public battles with substance abuse are regularly in the headlines. By the end of her life, Winehouse’s struggles had stretched to the point of becoming fodder for jokes and riddles (“Q: What was Amy Winehouse’s biggest hit? A: Her last one!”). Sadly, our society has grown so accustom to addiction that we now laugh it off. But for those in its grips, it’s no joke.

We asked LaTonya Mason Summers, a Charlotte, North Carolina-based mental health therapist, to comment on the realities of drug and alcohol addiction and what we can do to help those affected by it.

UrbanFaith: After Amy Winehouse’s death, the Huffington Post featured a commentary by Rabbi Shais Taub which asked the question, “Was the World Powerless to Stop Amy Winehouse?” In other words, are there addictions so strong and pervasive that they’re beyond human understanding and control? How would you answer that?

LaTonya Mason Summers: The word choice is interesting here, and I agree: the “world” was powerless to stop Amy Winehouse. But it was the “world” that fueled Winehouse’s addictions. Not “world” in the sense of the “earth,” but “world” as defined by Winehouse’s frame of reference — the background, culture, and lifestyle out of which she lived. Addictions are strong, pervasive and hard to understand and control, but it’s even more difficult when one tries to stop addiction by their own strength and understanding. It is reported that Winehouse died from alcohol poisoning. Drug and alcohol abuse is a byproduct of something far deeper. Oftentimes, it’s a symptom of low self-esteem, unresolved trauma and abuse, rejection and abandonment, and mostly fear. We do a great disservice to addicted persons when we focus on their addictions and ignore the underlying problems.

We see so many celebrity drug and alcohol addicts today that our culture has almost grown cold and callous to it. For instance, before her death there was a website devoted solely to the question of “When will Amy Winehouse die?” We see celebrities such as Winehouse, Lindsay Lohan, Whitney Houston, and Charlie Sheen, and we make jokes about them. How does this affect our culture’s understanding of addiction?

When we have a culture entertained by reality TV shows, court and crime TV, and sensationalized Web broadcasting — not to mention today’s popular music — we can’t help but have a desensitized society. We are no longer afraid of or empathetic toward anyone or anything because we’ve been there and done that through TV and the media. So, why wouldn’t we have a “When will Amy Winehouse Die?” website?

Unfortunately, we live in a society that “dumbs down” addictions but tacitly gives a “thumbs up” to its portrayals. Remember when there used to be cautionary documentaries on drugs and alcohol, and on people who struggled with them? Now, we have reality shows that glorify dysfunctional behavior. No wonder we are ignorant. Understanding addictions is no longer newsworthy.

How do you counsel a person with a serious drug addiction? Where do you begin, and what kinds of things should family and friends understand as they’re trying to help that person?

I used to set up and run treatment programs for adolescent and adult substance abusers. I absolutely loved that line of work, but it was emotionally tough. After 11 years of doing it, I stepped away to work solely with mentally ill people. The public sees addicted persons as weak people who lack self-control and deserve every consequence they face. But can you imagine the level of shame, guilt, frustration, and hopelessness that those substance abusers felt by the time they got to me? Imagine having failed everyone, including yourself, family, friends, employers, and the legal system — not to mention God. I always started treatment by instilling hope and restoring the addicted person’s sense of worth. It was much easier to establish rapport, trust, and motivation that way.

God forbid I say this, but oftentimes the families were more sick than the addicts. In fact, family members would wind up on my couch before the addict would. Family work is important in substance-abuse treatment, because the family members can make recovery hard. They help too much. Their helping sometimes hurts the addict. When my patients had toxic families, I’d send my patient to a treatment program in another city or state so they could get better.

Over the summer, former NBA star Jalen Rose was sentenced to 20 days in jail for drunk driving. Some wondered if the treatment was overly harsh because he was a black celebrity, since others have gotten off easier. Do you think jail time is an effective way to steer people clear of destructive behavior involving alcohol and drugs?

In my experience working in the court system as an advocate for my clients, the courts made it worse. The punishment given rarely fit the crime. The probation officers were inconsistent. The judges sent mixed messages by punishing minor crimes with maximum sentences and vice versa. Jail time is punitive, and punishment does not work when the drug or alcohol use is secondary to something else. Addicts don’t mind punishment because they typically feel useless and worthless anyway. That kind of punishment affirms what they believe about themselves. However, I am not saying they should not suffer consequences for drunk driving, drug use, etc. I am saying that offering them rehab while they’re incarcerated might yield greater results.

What kinds of miracles have you seen in your work with people battling addictions?

LaTonya Mason Summers

Goodness, the stories I can tell. I’ve had a hand in imparting into the lives of addicted persons who are now pastors, business owners, and even addictions counselors. I had a 15-year-old girl whose parents brought her to me as a last resort. She had refused other counselors, and I assumed she would do the same with me. After I asked her parents to leave, the girl opened up to me like a book. (It wasn’t because of anything special that I said to her, but other professionals simply had failed to remove the parents.) The girl was a cocaine user and held me by her confidentiality rights, so I could not tell her parents. We made a pact that if she stopped using I would keep her secret. I cannot tell you the anxiety I had for weeks thinking something would go wrong. I collaborated with her physician to drug test her weekly to ensure the girl’s abstinence. After three months, her parents called thanking me for my help. The girl had returned to a healthy weight, her appetite had been restored, and her mood had improved. Today (four years later) she is a successful college student studying psychology.

Among the celebrity success stories that stand out are Robert Downey Jr.’s eventual victory over substance abuse. It only came after several stints in jail and a long, public battle. What kinds of things contribute to a successful road to recovery, and when do you know that someone is legitimately recovered?

My biggest weapon is instilling hope. I do this by challenging the addicted person’s mentality and perspective. I am a cognitive behaviorist, which means I help change the way people think. I do not know what works, as I have often thrown up my hands on clients who later recovered. Then I have lost clients whom I thought had arrived. All I really know is, pray hard in each session. I ask for God’s help. I ask Him to give me the words to say, and I hold on toIsaiah 50:1-7, believing I am called as a therapist.

I honestly don’t know when a person is legitimately recovered, as I believe it’s a lifelong process. Like those of us who are not addicted, we have our own lifelong battles — we try to stop lying, cheating, stealing, yelling, cursing, overeating — everyone has a Goliath they must face. And can any of us say we’ll ever arrive in this world? From my perspective, messing up is just as much part of the recovery process as getting it right is. And, if you get it right all the time, how do you know you’re recovered?

Is it possible to effectively treat addiction without addressing the spiritual aspects of the problem? 

Absolutely not! I’ve had to learn how to minister without saying “God” and “Jesus,” so that I can reach everyone. However, I know how to make others want what I have. I was mentored by a man who told me, “I may not be able to make a horse drink the water, but I should be able to make him thirsty.” And that’s the approach I take in therapy. I see myself as sowing seeds, believing someone will come behind me and water them, and eventually increase will come.

Addiction is spiritual. I believe an addict’s zealousness can be indicative of the great calling on his life. He just needs to move that zealousness away from destructive behavior to purposeful, life-giving behavior.

 

A GANG of drug dealers planned to flood Britain with £4 billion of cocaine - arranging the plot from a phone box.

The Liverpool and London-based gangsters were planning to smuggle 40 tonnes of cocaine from South America by sea, hidden inside tins of fish and wooden pallets.

Liverpool Crown Court heard that the drug would be bought at a "wholesale price" and then sold to other dealers who would dilute it and sell it on.

If all the cocaine had made it to the streets of the UK and it was cut before being sold, the court heard it could have been worth around £4 billion.

The head of the Liverpool operation used a phone box in Old Hall Street, in Liverpool city centre, to arrange the deal with his London counterpart.

But the gang were being watched by undercover officers from the Serious and Organised Crime Agency (Soca).

The phone box on Old Hall Street used by one of the drug dealers

The group was led by Mehmet Sirin Baybasin, 48, of Fairfield Crescent, Edgware, north-west London, who was jailed for 30 years at a hearing last week after he was found guilty of conspiracy to import cocaine.

The court heard that Baybasin was one of a total of 24 defendants brought to justice as part of the Soca investigation and that he was "at the top of the pyramid".

Judge David Aubrey QC said the offences had "at their core the evil and pernicious trade of drug dealing" and were indicative of the gang's "desire for the good life".

He said he was satisfied that the amounts they were talking about were not "pie in the sky" and that the wholesale value of 1,102lb (500kg) of uncut cocaine alone was worth a potential £17 million

Troubled: Amy Winehouse on stage in Serbia a month before she died

TRAGIC Amy Winehouse died after a killer booze bender following weeks on the wagon, her inquest was told yesterday.

The Back to Black star, 27, who had fought drug and alcohol problems for years, was discovered lifeless in bed at her North London home on Saturday, July 23.

In June, she had stumbled around the stage during a shambolic concert in Belgrade, Serbia, where she was booed off after slurring through songs.

And as tearful parents Mitch and Janis listened yesterday in the public gallery, the hearing was told Amy did not drink for the first three weeks of July.

Tears: Amy's dad Mitch Winehouse and stepmum Jane arrive at the Coroners' Court (Pic: Getty)

But she then hit the bottle days before her death – and the Mirror reported at the time she was spotted necking shots at the Roundhouse venue near her Camden home after dramatically falling off the wagon.

Giving evidence yesterday, her GP Dr Christina Romete said this fitted a pattern in which Amy would abstain from alcohol for weeks, only to drink again. The doctor revealed she warned the star of the many dangers if she kept drinking.

Dr Romete said: “The advice I had given to Amy over a long period of time was verbal and in written form about all the effects alcohol can have on the system, including respiratory depression and death, heart problems, fertility problems and liver problems.”

Amy, who won five Grammy awards in 2008, was taking medication to cope with alcohol withdrawal and anxiety. She was reviewed last year by a psychologist and psychiatrist about her drinking but “had her own views” about treatment.

The GP, who treated her for several years, said her patient fully understood the risks of continuing to drink. Dr Romete said the night before her death, Amy was “tipsy but coherent” and said she did not know if she was going to stop drinking but “she did not want to die”.

Amy had no illegal drugs in her system when she died but police found three empty vodka bottles in her bedroom – two large and one small.

She was using alcohol withdrawal drug Librium and sleeping tablets but the inquest heard they had not played a part in her death.

At St Pancras Coroner’s Court in London, it emerged she had 416mg of alcohol per 100ml of blood in her system, with the legal driving limit being 80mg

High Court judge found that the Financial Services Authority (FSA) had wrongfully used privileged emails to bring its case against Keydata. A further "relief hearing" will now determine the impact of the ruling, which could de-rail the case altogether. It is the latest in a line of setbacks for the regulator, which has been investigating regulatory breaches at Keydata and millions of pounds of missing retail funds for two years. Keydata invested in "life settlement funds", which buy and sell US life insurance and generate high returns. In June 2009 the FSA applied for Keydata's closure "to protect investors", saying it was concerned about "potentially missing assets". The business was fast-tracked into administration and referred to the Serious Fraud Office (SFO). It emerged that £103m of life insurance policies managed by a Luxembourg business, SLS Capital, and sold to Keydata investors as low-risk bonds might have been "misappropriated".

US Attorney General Eric Holder says the alleged conspiracy was "conceived, sponsored and directed from Iran" Continue reading the main story Related Stories Clinton hails break-up of 'plot' Middle East rivalries play out in US The US secretary of state has called for a "very strong message" to be sent to Iran, after allegations of a plot to kill the Saudi ambassador to the US. Hillary Clinton said Washington was preparing new penalties against Iran, which is already subject to a variety of international sanctions. Two Iranians were charged over the plot which US officials said implicated Iran's Revolutionary Guard Corps. Meanwhile the US issued a worldwide alert about possible anti-US actions. "The US government assesses that this Iranian-backed plan to assassinate the Saudi ambassador may indicate a more aggressive focus by the Iranian government on terrorist activity against diplomats from certain countries, to include possible attacks in the United States," the alert said. It urged Americans residing and travelling abroad to review the information available when making travel plans. Iran has dismissed the allegations as false and baseless. Continue reading the main story “ Start Quote The idea that they would attempt to go to a Mexican drug cartel to solicit murder-for-hire to kill the Saudi ambassador, nobody could make that up, right?” Hillary Clinton US secretary of state 'Well-grounded suspicions' Mrs Clinton praised those involved in the operation to uncover the plot. "It was a terrific achievement by our law enforcement and intelligence communities, and we will be consulting with our friends and partners around the world about how we can send a very strong message that this kind of action, which violates international norms, must be ended," she said at a news conference. "This case will, I think, reinforce the well-grounded suspicions of many countries about what they're up to." Mrs Clinton said the suspected plotters had been trying to involve hired killers from Mexican drug cartels. "The idea that they would attempt to go to a Mexican drug cartel to solicit murder-for-hire to kill the Saudi ambassador, nobody could make that up, right?" she said. US Attorney General Eric Holder said Iran's involvement in the plot was "a flagrant violation of US and international law". Continue reading the main story Analysis Mohammad Manzarpour BBC Persian There is a long history of animosity between Iran and Saudi Arabia which stretches back to before the Islamic Revolution of 1979. Religiously, the Wahhabi rulers of Saudi Arabia and the Shia clerics of Iran reject each other's interpretation of Islam. Geopolitically, the two are staunch rivals, engaged in a seemingly never-ending battle for greater regional influence. They have also been engaged in proxy wars for decades, taking different sides in the Iran-Iraq war, Afghanistan, Lebanon and the Palestinian territories. But it is the Saudis' military intervention in Bahrain which may have prompted the alleged plot. It was little criticised in the West but was seen in Iran as a blatant assault on the Shia majority in Bahrain. In a statement, UK Prime Minister David Cameron's office said: "Indications that this plot was directed by elements of the Iranian regime are shocking... We will support measures to hold Iran accountable for its actions." US officials have said military action was not being considered. The US Treasury Department placed five Iranians, including the two men charged, under sanctions on Tuesday for their alleged involvement in the plot. The two accused were named as Manssor Arbabsiar, a 56-year-old naturalised US citizen with dual Iranian and US passports, and Gholam Shakuri, based in Iran and said to be a member of Iran's Quds Force, a unit of the Revolutionary Guard Corps. The other three were described as high-ranking members of the Quds force. Mr Arbabsiar, who was arrested at New York's John F Kennedy airport on 29 September, has confessed to his involvement in the alleged plot, Mr Holder said. A lawyer for Mr Arbabsiar said he would plead not guilty when he was officially indicted. 'Shocking' Mr Shakuri was said to be in Iran. US officials said that on 24 May 2011, Mr Arbabsiar made contact with an informant for the US Drug Enforcement Agency, who was posing as a Mexican drug cartel member. Manssor Arbabsiar appeared at a court in New York City on Tuesday Over a series of meetings, it is said that details emerged of a conspiracy involving members of the Iranian government paying $1.5m (£960,000) for the assassination of Saudi ambassador Adel al-Jubeir on US soil. Justice department officials said the initial envisaged target was the Saudi embassy. But in conversations secretly recorded for the US authorities, Mr Arbabsiar also allegedly considered having the ambassador killed at a purported favourite restaurant, despite the possibility of mass casualties. The plot would have been carried out with explosives, Mr Holder said. But he added that no explosives were ever put in place and the public was not in danger. Mr Holder said Mr Arbabsiar, with approval from Mr Shakuri, wired $100,000 to a US bank account for the informant as a downpayment. Mr Arbabsiar and Mr Shakuri have been charged with conspiracy to murder a foreign official, weapons conspiracy, and conspiracy to commit international terrorism charges. Continue reading the main story “ Start Quote The choice of ambassadorial target is a direct expression of the acerbic tensions in the Middle East between Saudi Arabia, a key US ally, and Iran” Kim Ghattas BBC News, Washington Alleged plot reflects Middle East rivalries Unnamed US officials also told journalists that the Israeli embassy in Washington was also to have been attacked. Iran's official Islamic Republic News Agency called the charges a "propaganda campaign" by the US government against Tehran. The allegations were "a comedy show fabricated by America", Iranian foreign ministry spokesman Ramin Mehmanparast told the semi-official Iranian news agency, Fars. Mr Arbabsiar appeared briefly at a New York City court on Tuesday. He did not enter a plea and was held without bail. He could face a life prison sentence if convicted on all charges, the Department of Justice said.

The US State Department late on Tuesday issued a worldwide travel alert for US citizens, warning of the potential for anti-US action after the United States accused Iran of backing a plot to kill Saudi Arabia's ambassador to Washington.   Murder Plot Iranians charged over assassination plot / Reuters American authorities uncover plot to bomb Israeli, Saudi embassies in Washington, assassinate Saudi ambassador Full story "The US government assesses that this Iranian-backed plan to assassinate the Saudi ambassador may indicate a more aggressive focus by the Iranian government on terrorist activity against diplomats from certain countries, to include possible attacks in the United States," it said in a statement on its website.   The alert expires January 11, 2012, it said.

Boris Berezovsky said Mr Abramovich was part of “black ops” by the Russian security service designed to force him to give up his business interests in the country. Mr Berezovsky, the so-called “godfather” of the Russian oligarchs, says he met Vladimir Putin, the Russian leader, at the Kremlin “eye to eye” and was told to give up his control of a television station that had criticised the president over his handling of the sinking of the nuclear submarine the Kursk. When he refused, he was threatened with arrest and policemen in balaclavas, dubbed “maski” stormed the TV station ORT to remove documents. Mr Berezovsky says he fled the country and Mr Abramovich, his former protegee took advantage of the situation to pressure him into selling both ORT and the oil conglomerate Sibneft they had created together. Mr Abramovich is then said to have sold his minority stake in the aluminium giant Rusal, massively devaluing Mr Berezovsky’s stake.

The King of Pop's three children 'cried and cried and cried' after being told their father was dead.

His daughter, Paris, now 13, told Murray, her father's personal doctor: 'I will wake up in the morning and I won't be able to see my daddy.'

On Tuesday a court in Los Angeles heard recordings of Conrad Murray saying Michael Jackson's children sobbed when they learned their father died and saw a photo of the singer's dead body

According to the 58-year-old cardiologist, she said: 'Dr Murray, you said you save a lot of patients. You know, you save people with heart attacks, and you couldn't save my dad.'

Paris's anguish was revealed in an interview Murray gave to detectives two days after Jackson's death on June 25, 2009.

The court saw a photograph of the painfully thin star taken before an autopsy was carried out on his body the day after his death. It was the second time the jury has seen a photo of the dead star after a picture was displayed on the opening day of the trial.

 Jackson's mother, Katherine, who flew back to Los Angeles from the weekend tribute to her son in Wales, left the courtroom before the disturbing image was shown on a screen.

Dr Christopher Rogers, Los Angeles Deputy Medical Examiner, said the 5 ft 9 ins tall singer was comparatively fit when he died.

Enlarge  

A coroner's photo of Jackson's naked body, with his genitals blacked out, was shown to jurors as they heard he was relatively fit for his age, but had many puncture wounds on his arms and legs from injections

'He was healthier than the average person of his age,' said Dr Rogers, who added there was no sign of any fat or cholesterol on the walls of Jackson's heart.

He ruled the cause of death was homicide as a result of acute Propofol intoxication, the court heard.

Dr Rogers dismissed Murray's claims that the singer took a deadly dose of Propofol himself while the doctor left his bedside for two minutes to go to the toilet. 

He suggested it was too short a time for Jackson to be able to self-administer the drug and for it take sufficient effect to stop his breathing.

He said Murray had no equipment to help deliver the correct amount of Propofol to help Jackson sleep.

Enlarge  

A close up of Jackson's wrist shows his date of death, which was actually June 25, 2009 but mis-labelled as August, and Coroner Case Number 2009-04415

'It would be easy for the doctor to estimate wrongly and give too much Propofol,' he added.

Murray, who has pleaded not guilty to a charge of involuntary manslaughter, is not expected to testify at the trial at Los Angeles Superior Court, but the recording means jurors at least got to hear his side of the story.

Before Rogers the last 45 minutes of the two-hour tape was played in the hushed courtroom on Tuesday.

Murray told police Jackson's children 'really were weeping, really weeping' when they were told that doctors at UCLA Medical Centre in Los Angeles had been unable to revive their 50-year-old father.

'I hugged them all, gave comfort to Paris, comfort to Prince, comfort to Blanket, which is the last little guy, because whenever they were sick, they would always ask for Dr Conrad,' he said.

Addiction Recovery: Many of us have wasted a lot of time doing that and it doesn't work. You can easily see why.

We usually conclude the period of meditation with a prayer that we be shown all through the day what our next step is to be, that we be given whatever we need to take care of such problems. We ask especially for freedom from self-will, and are careful to make no request for ourselves only. We may ask for ourselves, however, if others will be helped. We are careful never to pray for our own selfish ends. Many of us have wasted a lot of time doing that and it doesn't work. You can easily see why.

age of miracles is still with us.  Our own recovery proves that!