Two-thirds of smokers try to quit in new year

 

Two-thirds of smokers in the UK, approximately six million people, will try and quit the habit in January, but half of them will fail within a week, new research suggests. According to the study, commissioned by Pfizer Limited in support of its Don't Go Cold Turkey disease awareness campaign, one in ten of these attempts will not last beyond 24 hours. Typically, smokers admit to having unsuccessfully attempted to quit three times before, with 51 per cent confident they can kick the habit in the next six months. Some 45 per cent say they attempt to quit by 'going cold turkey' or giving up the immediately and relying on willpower, however only three per cent of these people are found to be smoke free after a year. Nearly a quarter of former smokers recommend that people trying to quit consult a healthcare professional. Dr Sarah Jarvis, BBC medical correspondent and practising GP, said: "Even a brief conversation with their healthcare professional or local stop smoking service can increase [a smoker's] chances of success by up to four times, compared to going 'cold turkey'. "People should consider how they can positively influence their chances of quitting." According to Cancer Research UK, 86 per cent of lung cancer deaths are caused by tobacco smoking.

there is an area in your brain where you may hold a reservation and that could, in all likelihood, cause you to return to your drinking. I wish that I might reach this place in your consciousness, but alas, I do not have the skill."

Twelve Step people who study A.A.'s Big Book are, of course, familiar with Bill Wilson's medical mentor, Dr. William Duncan Silkworth. Bill called him the benign "little doctor who loved drunks." Silkworth, a psychiatrist, had treated thousands of alcoholics and was director of Towns Hospital in New York where Bill had several times sought help. Though Silkworth had explained the disease of alcoholism to Bill, Bill continued to drink until he met his "sponsor" Ebby Thacher, who had recovered through the spiritual program of the Oxford Group. Ebby had also gone to Calvary Rescue Mission, run by Dr. Sam Shoemaker's Calvary Episcopal Church in New York; and Ebby had there made a decision for Christ. Wilson went there for the same purpose and, according to a conversation the author had with Dr. Shoemaker's widow (Helen Smith Shoemaker), Bill Wilson made a decision for Christ at the Rescue Mission. Bill stayed drunk for a few days and then checked into Towns Hospital and again sought help from Dr. Silkworth. And it was during this stay, that Bill took the life-changing steps of the Oxford Group, had his "hot flash experience," reported it to Dr. Silkworth, and was told by Silkworth that he (Bill) had better hang on to what had happened to him. Silkworth later was asked to write the "Doctor's Opinion" that opens the basic text of the Big Book. Silkworth's picture appears in A.A.'s Pass It On, the biography of Bill's life.

        Shortly before his death, the author spent an hour with Dr. Norman Vincent Peale, friend of A.A., the Rev. Sam Shoemaker, and Bill Wilson. Dr. Peale told me of the conversations he had with Bill Wilson about Bill's conversion. However, until 1997, I had never heard the following account by Peale about Dr. William Duncan Silkworth. It can be found in Norman Vincent Peale, The Positive Power of Jesus Christ (New York: Foundation for Christian Living, 1980), pp. 60-61. It appears under the title "The Wonderful Story of Charles K.":

        Charles, a businessman in Virginia, had become a full-fledged alcoholic; so much so that he had to have help, and fast, for his life was cracking up. He made an appointment with the late Dr. William Duncan Silkworth, one of the nation's greatest experts on alcoholism, who worked in a New York City hospital [the Charles Towns Hospital]. Receiving Charles into his clinic as a patient, the doctor gave him treatment for some days, then called him into his office. "Charles," he said, "I have done everything I can for you. At this moment you are free of your trouble. But there is an area in your brain where you may hold a reservation and that could, in all likelihood, cause you to return to your drinking. I wish that I might reach this place in your consciousness, but alas, I do not have the skill."

        "But, doctor," exclaimed Charles, "you are the most skilled physician in this field. When I came to you it was to the greatest. If you cannot heal me, then who can possibly do so?" The doctor hesitated, then said thoughtfully, "There is another Doctor who can complete this healing, but He is very expensive."

        "That's all right," cried Charles, "I can get the money. I can pay his fees. I cannot go home until I am healed. Who is this doctor and where is he?"

        "Oh, but this Physician is not at all moderate as to expense," persisted Dr. Silkworth. "He wants everything you've got. He wants you, all of you. Then He gives the healing. His price is your entire self." Then he added slowly and impressively, "His name is Jesus Christ and He keeps office in the New Testament and is available whenever you need Him."

        Dr. Peale then describes the healing of Charles through the power of Jesus Christ. 

Recovering alcoholic Matt Maden: I began drinking at 10 and now I'm facing death at 26

 

Matt Maden, now 26, has been living on borrowed time since he was diagnosed with liver cirrhosis five years ago. Despite his desperate need he has only a 20 per cent chance of getting an organ because of the growing demand. ‘It’s really scary living with the knowledge that the odds are so heavily against you,’ he said. His condition was detected when he spent two weeks in hospital in an alcohol-induced coma – but even then he refused to believe he had a problem. ‘My immediate thought was, “It’s not the drink”,’ he said. The first time Mr Maden got drunk was at 15. ‘I remember waking up the next morning and my first thought was, “When can I do that again”,’ he said. Within a year he went from drinking eight cans of lager in a session to 16 in order to get a buzz. ‘After a couple of years I’d have to have maybe a bottle of spirits to go along with that,’ he added. ‘For a lot of years alcohol gave me  confidence. Little did I know it would actually turn on me and it would start to control me.’ After his health scare Mr Maden left his home in Oxford to check into a rehab clinic in Bournemouth and has not touched a drop since 2007. His physician, Dr Varuna Aluvihare, from King’s College London, believes the binge-drinking culture is behind the increasing number of young people needing liver transplants. ‘Tragically, every year we fail to keep someone like Matt alive,’ he said.

Money spent on nicotine patches 'goes up in smoke', says survey

 

Those who go cold turkey have just as much chance of quitting the habit long-term, the study published on Monday added. A total of 787 adult smokers trying to quit were followed over five years by researchers at Harvard School of Public Health. One in three relapsed with the numbers spread equally between those going ‘cold turkey’, those using nicotine patches, gums or sprays, and those combining nicotine replacement with counselling. Heavy smokers who used nicotine replacement products without any professional therapy were twice as likely to relapse. Lead author Hillel Alpert said: ‘Some heavily-dependent smokers perceive nicotine replacement therapy (NRT) as a sort of “magic” pill. ‘Upon realising it is not, they find themselves without support in their quitting efforts, doomed to failure.’ But the findings sparked a backlash from the NRT industry, which is worth £150million in Britain and £520million in the US. GlaxoSmithKline, which makes Nicorette gum, said studies show NRT products, combined with support, ‘can double’ smokers’ chances of quitting

Once powerful Mexican drug lord Benjamin Arellano Felix pleaded guilty in a U.S. federal court on Wednesday to drug trafficking, racketeering and money laundering charges

 

. Arellano Felix, 58, was the head of the feared Tijuana cartel run by his brothers and operated on the Mexico-U.S. border near San Diego until his capture in Mexico in early 2002. He was extradited to the United States last April, and prosecutors said his guilty plea marked the demise of the violent cartel that dominated smuggling on the California-Mexico border in the 1980s and 1990s. "Arellano Felix led the most violent criminal organization in this part of the world for two decades. Today's guilty plea marks the end of his reign of murder, mayhem and corruption," U.S. Attorney Laura Duffy said. "His historic admission of guilt sends a clear message to the Mexican cartel leaders operating today: The United States will spare no effort to investigate, extradite and prosecute you for your criminal activities," she added. As part of a 17-page plea agreement, Arellano Felix admitted smuggling tons of cocaine and marijuana into California and conspiring to launder hundreds of millions of dollars. He also agreed to forfeit $100 million in profits under the plea deal, which is expected to land him 25 years in federal prison when he is sentenced on April 2. "It was a favorable deal to my client who faced a minimum of 40 years and a maximum of 140 years under the extradition agreement," defense attorney Anthony Colombo Jr. said. CARTEL A SHADOW OF FORMER SELF President Barack Obama's administration has worked closely with Mexican President Felipe Calderon in his army-led battle to crush warring drug gangs in a conflict that has claimed more than 46,000 lives since late 2006. At the height of his power in the 1990s, Arellano Felix smuggled hundreds of millions of dollars in narcotics through a 100-mile wide corridor stretching from Tijuana, south of San Diego, to Mexicali, south of Calexico. But after the death and capture of many of its leaders over the past decade, including three of Benjamin Arellano Felix's brothers, the Tijuana cartel, also known as the Arellano Felix Organization, is a shadow of its former self. Arellano Felix's brother Ramon, the cartel's flamboyant enforcer, died in a shoot-out in 2002. Francisco Javier is serving a life sentence in U.S. federal prison after being captured on a fishing boat in 2006, and Eduardo is in jail in Mexico awaiting extradition. With the downfall of the Arellano Felix brothers, the rival Sinaloa cartel run by Mexico's most-wanted man, Joaquin "Shorty" Guzman, has largely taken over the cartel's valuable turf in Tijuana. Appearing before U.S. District Judge Larry Burns at the hearing, Arellano Felix was neatly groomed and dressed in an orange jumpsuit. He said he took medication for migraine headaches, but when asked by the judge if it affected his decision to plead, he replied, "no." Among the former kingpins serving time in U.S. jails is former Gulf cartel leader Osiel Cardenas, who was extradited to the United States by Mexico in 2007 and is serving a 25-year sentence in Texas without chance of parole.

Drug smuggling bid foiled

 

Customs at the airport foiled an attempt by one Egyptian expatriate arriving from Cairo to smuggle 1,000 narcotic pills into the country. The concerned officers said the suspect had kept the contraband hidden in his shoes when they discovered it. He has since been handed over to Drug Prosecution. In a statement following discovery of the illicit drug, the Director General of Customs Ibrahim Al-Ghanim commended efforts exerted by customs men to uncover complicated smuggling cases.

Drug smuggling compartment specialist sentenced to 24 years

A California man who specialized in building secret compartments in vehicles used to smuggle drugs received a 24-year sentence in what prosecutors said was one of the first cases against a specialist who worked for drug dealers but didn’t directly handle the drugs. Alfred Anaya, 40, a native of San Fernando, CA, was sentenced to 292 months in federal prison and forfeiture of $3.2 million. Anaya, said a Jan. 6 statement from the U.S. Attorney’s Office in Kansas, operated in the state. “Evidence showed the defendant installed sophisticated hidden compartments in dozens of vehicles,” said U.S. Attorney Barry Grissom. “He knew he was working for drug traffickers.” Anaya was convicted on one count of conspiracy to possess with intent to distribute more than five kilograms of cocaine, as well as methamphetamine and marijuana, and two counts of attempting to intimidate a witness, said the statement. Convicted in the case along with Anaya were James Clark, 29, of Overland Park, KS, who was given a sentence identical to Anaya’s on the same charges. Curtis Crow, 30, of Leawood, KS, was sentenced to 147 months on conspiracy and drug distribution charges. Anaya and Clark were convicted in Feb. 2011 and Crow pleaded guilty, said the statement. Prosecutors showed the men were members of a California-based drug trafficking organization that operated a drug distribution center in Kansas between 2008 and 2009 that distributed cocaine, methamphetamine and marijuana in Kansas and Missouri. Prosecutors also presented evidence that Anaya installed secret compartments including a 20-kilogram compartment in a Ford F-150, a 10-kilogram compartment in a Honda Ridgeline, a 3-kilogram compartment in a Toyota Camry and a 10-kilogram compartment in a Toyota Sequoia.

Britons who take cocaine are destroying Colombia and killing Colombians

Britons who take cocaine are destroying Colombia and killing Colombians, the country’s president says.

In an exclusive interview at the presidential palace in Bogotá, Juan Manuel Santos highlighted the price paid by the South American nation for the cocaine trade ahead of a visit to Britain later this month.

Colombia is emerging from a four decade-long civil war involving both left-wing guerillas like Farc and right-wing paramilitaries, who have been funded by drug trafficking.

Mr Santos, 60, said Colombia, the world centre of the cocaine trade, had suffered more than any other country in the world from the West’s insatiable appetite for the drug.

He said: ‘I say that every time somebody in London sniffs coke he destroys the environment here in the tropical forests – because it stimulates deforestation – and probably kills a couple of people.’

The president, who swept to power last year after a landslide election victory, has urged world leaders to consider a new approach to tackling drugs and said he was prepared to legalise marijuana if other countries did the same.

Mr Santos said he would even consider legalising cocaine as a possible solution and insisted Colombia had a ‘certain moral authority to discuss this issue’ as it has lost so much from the drugs trade.

A key priority for Colombia – in common with other Latin American countries such as Mexico, which have seen thousands killed in drug-related violence – is reducing demand in the US and Europe.

‘What I think the world should do is sit down and rationally discuss this problem which is growing – it’s not diminishing, it’s growing,’ he said.
Mr Santos added: ‘We are willing to explore new avenues but in the meantime we need to continue our policy of attacking each link of the chain because for us it’s a matter of national security.

‘The drug trafficking is what finances all of the violent groups in Colombia. We are the country who has suffered most, more than any other country, so for us we have no alternative in the meantime but to fight, with everything we have, the cultivation, the labs, money laundering, the assets, consumption – all the links in the chain.’ The affable London-educated politician and former journalist was in buoyant mood just three days after announcing how government troops had killed 63-year-old Alfonso Cano, the leader of Marxist rebel group Farc, in his jungle hideout.

He said: ‘This is the biggest blow to Farc in their history. What happened to Cano is proof we can take any of them, anywhere.’

But Mr Santos is aware that despite a rapidly growing economy, described as an ‘ideal market for British companies’, the country still has far to go – Colombia has the worst human rights record in the western hemisphere and leads the world in killings of trade unionists.

Mr Santos, who said he has ‘clicked’ with David Cameron and remains a ‘very good friend’ of Tony Blair, said: ‘Of course there room for improvement, we’re still not a paradise. I’m the first one to recognise that and that’s why we have to redouble our efforts.’

Chicago area had the most heroin-related hospital visits in the nation.

 

2010 study by Roosevelt University researchers found the Chicago area had the most heroin-related hospital visits in the nation. The drug is cheap, and it's attracting users everywhere including some who are very young. Today's heroin can be snorted or smoked -- not just injected -- and that's led to a change in the typical user. Increasingly, today's addict is young, female and from the suburbs. And the roots of their addiction can be found in their family's medicine cabinet. For many, the road to dependence begins at independence --one of a handful of West Side exits off the Eisenhower serve as the gateway to the nation's busiest heroin corridor. "The ride there you're just anxiety, just, 'Oh I can't wait to get there. I can't wait to get it. I can't wait to feel better,'" said a 19-year-old female heroin addict whose scar are more than skin deep. She grew up far from the west side's rough and tumble streets, amidst the manicured lawns of the far west suburbs which seems an unlikely breeding ground for a new crop of heroin users. "I always thought of them as homeless and not caring about what they look like and real skinny and everything," the 19-year-old addict said. Heroin has never been cheaper and more pure. Just $100 can buy a two day supply. "I knew. The first time I did it I was like, 'This is bad. I like this way too much. And this is going to be bad," said the 19-year-old addict, whose identity ABC7 has hidden. DEA Agent Jack Riley says powerful Mexican drug cartels have partnered with Chicago street gangs to make heroin easily available. "If I had to liken anything to a weapon of mass destruction, it would be heroin," Riley said. After smuggling the drugs here, Riley says the cartels often operate in Spanish-speaking areas near Midway Airport. "They can assimilate into these hard working neighborhoods. They can appear to be great citizens, take care of their lawn, put Christmas lights up," Riley said. The cartels need the gangs to distribute the drugs but officials say fights between the two groups are increasingly to blame for the near-daily violence plaguing some neighborhoods. "What we consider to be senseless violent acts, many of them may be actually connected to the cartel's operations in Chicago," Riley said. It seems the danger is of little deterrent to users. "Within two weeks I was getting sick physically without it, and I needed it," the 19-year-old addict said. It wasn't until an overdose nearly killed her that she began treatment a few weeks ago at New Hope Recovery Center in Geneva. In four years, the facility has seen a seven-fold increase in heroin cases and many involve teens first hooked on prescription painkillers. "They'll run out, and someone will say 'Well, snort some heroin. It'll help you, so you won't go through withdrawals,'" said Jake Epperly, New Hope Recovery Center. That may have been how Billy Roberts began using. The Homer Glen 19-year-old died of an overdose two years ago and his father now warns of heroin's dangers. "I do it for him," said the victim's father John Roberts. "And I'll continue doing it as long as I'm alive. To give my son's life meaning. A former Chicago cop, Roberts says it's time for new solutions. "We need help. The police cannot do this alone. We need a comprehensive, strategic approach to this problem if we're ever going to see these numbers turn downward," Roberts said. To put in perspective how big the problem is here, the Chicago DEA has secured funding for a 90-person strike force to combat the operation run by the cartels and gangs in the city. Officials say it's the only such strike force outside of the U.S.-Mexico border. The 19-year-old woman interviewed by ABC7, who is currently in treatment, says she knows at least 20 other kids her age, from her community, who are current or former users.

Roxies sell on the street for as much as $30 per pill and offer a high that tops crack, heroin or meth

Michael Patrick/news sentinel The two most wanted prescription pills on the streets of East Tennessee. The small pills are Roxie 30 and the large green pill is an Oxycontin 80. The second-generation Oxys, made by Purdue Pharma, are now wrapped in a sticky gelcap coating that will burn nostrils and resists needles.

PHOTO BY MICHAEL PATRICK, COPYRIGHT © 2011 // BUY THIS PHOTO

Michael Patrick/news sentinel The two most wanted prescription pills on the streets of East Tennessee. The small pills are Roxie 30 and the large green pill is an Oxycontin 80. The second-generation Oxys, made by Purdue Pharma, are now wrapped in a sticky gelcap coating that will burn nostrils and resists needles.

Effects of oxycodone: The high caused by oxycodone and other opiates affects nearly every major organ in the human body. So does withdrawal. This chart illustrates some of those effects.

PHOTO BY SOURCE: U.S. DRUG ENFORCEMENT ADMINISTRATION, NATIONAL INSTITUTE ON DRUG ABUSE

Effects of oxycodone: The high caused by oxycodone and other opiates affects nearly every major organ in the human body. So does withdrawal. This chart illustrates some of those effects.

Oxy's out. Roxies rule.A tiny blue pill, no bigger than a baby aspirin, overshadows nearly every other illegal drug on the market in East Tennessee. Men and women beg, haggle, threaten, lie, steal and kill — all for a handful of pills.

"It's the new crack," Knox County Sheriff's Office Lt. John Hopkins said. "Most of the addicts we see don't even shop for Oxys now. They've all switched to Roxies, and it's worse than crack ever was."

Doctors, police and emergency workers see the fallout every day. Sometimes it's a pill-sick addict who steals today to buy tonight's fix. Sometimes it's a baby born shaking with seizures from withdrawal.

Oxycontin: A time-release form of oxycodone, an opioid painkiller, produced by Purdue Pharma and used to treat chronic pain. Strengths range up to 80 mg per pill. Nicknames include Oxys, O's and hillbilly heroin.

Roxicodone: Instant-release form of oxycodone produced by Xanodyne Pharmaceuticals and used to treat breakthrough pain. Strengths range up to 30 mg per pill. Nicknames include Roxies, blues and stars.

Opana: Time-release form of oxymorphone, a synthetic opioid, produced by Endo Pharmaceuticals. Nicknames include stop signs, biscuits, octagons and Mrs. O.

Methadone: Synthetic opioid, typically prescribed in pill or wafer form, used to treat pain and to ease withdrawal symptoms for opiate addicts.

Percocet, Endocet, Roxicet: Mixtures of oxycodone and acetaminophen.Percodan, Endodan, RoxiprinMixtures of oxycodone and aspirin.

Vicodin, Lortab, Lorcet: Mixtures of hydrocodone and acetaminophen. Nicknames include Vikes and hydros.

Fentanyl: Synthetic opioid, stronger than morphine, typically prescribed in patch or lollipop form. Nicknames include china white and perc-a-pop.

Xanax: Brand name of alprazolam, a benzodiazepine produced by Pfizer and used to treat panic, anxiety and insomnia. Strengths range up to 2 mg. Nicknames include footballs and totem poles.

Valium: Brand name of diazepam, a benzodiazepine produced by Roche and used to treat panic, anxiety and insomnia. Strengths range up to 10 mg.

Klonopin: Brand name of clonazepam, a benzodiazepine produced by Roche and used to treat panic, anxiety and insomnia. Strengths range up to 2 mg.

Ambien: Brand name of zolpidem tartrate, a sedative produced by Sanofi-Aventis. Strengths range up to 10 mg.

Suboxone: Combination of buprenorphine and naloxone, used to treat opiate withdrawal.

Sometimes it's a corpse — a dealer killed for pills or an addict who chased the last high off the edge of oblivion.

Oxycodone hydrochloride tablets sell at the pharmacy counter under the brand name Roxicodone and offer quick relief from chronic pain for the old, the aching, the crippled and the dying.

Roxies sell on the street for as much as $30 per pill and offer a high that tops crack, heroin or meth — all without the pesky time-release formula that coats Oxycontin, the drug's sister medication.

"It's the epidemic of the day," Knoxville Police Chief David Rausch said. "Everything is attached to it now. Our investigators will tell you that 90 percent of the folks we see who've committed a crime say it's to get their medicine. That's what they call it — medicine.

"The days of the crack dealer on the corner are slowly waning. It's become the medicine dealer on the street."

Drugs of choice

Three people died last year in South Knox County when two men broke into a former police officer's house to steal legally prescribed painkillers. Police say a North Knoxville man's stepson beat him and his wife to death in August to steal pain pills, then burned down the house to cover up the crime.

A rash of drugstore robberies last fall and winter set a local record. Semiannual drug roundups keep rural jails packed and court dockets clogged.

Officers on the beat report dealing with addicts desperate to avoid jail and the agonies of withdrawal. Sometimes they run. Sometimes they fight.

"We're out here beating the bushes today, and in a few months we'll be out here again doing the same thing," said Capt. David Honeycutt, chief investigator for the Claiborne County Sheriff's Office, as he headed out with a stack of indictments in another drug roundup. "Pills have changed the face of law enforcement. It used to be pot, maybe Valium. Now it's pain pills, and they're crazy as hell on them. You'd be hard-pressed to find a family that's not been hurt by these drugs."

Tennessee topped the nation last year in busts of methamphetamine labs, where addicts churn out toxic waste breaking down cold and sinus pills to produce a homemade stimulant. Meth hasn't gone away, but police say they spend more time and money now fighting to keep the cap on the prescription bottle.

"People are afraid of meth, because everybody doesn't do meth," Newport Police Chief Maurice Shults said. "Everybody doesn't do crack. But everybody's on pills of some kind. Pills come from a doctor. People see that as safe. A doctor gives them out, so they've got to be good."

From Oxy to Roxies

Purdue Pharma's Oxycontin tablets once stood as the gold standard for opiate abusers, with concentrated doses of up to 80 mg of oxycodone locked inside a time-release formula easy to crack. Addicts crushed the pills to powder, then snorted or injected them to turn 12 hours of pain relief into an instant high.

That golden egg gained an extra shell when Purdue introduced a new formula last year meant to cut down on abuse. The second-generation Oxys come wrapped in a sticky gelcap coating that burns nostrils and resists the needle.

Some addicts claim to have found ways to beat the coating. Most don't bother.

Roxicodone and its generic equivalents deliver smaller doses of the same drug to treat the short, sharp bursts of breakthrough pain that plague cancer patients and others between round-the-clock doses of painkillers like Oxy. The pills come in 15 mg and 30 mg strength with no gelcap and no time-release coating, ready to deliver instant relief — or an instant high.

"There's no preparation," said Officer Phil Jinks of the Knoxville Police Department's Repeat Offender Squad. "It's straight out of the bottle."

The easy access and potential for profit have caught on among young and old.

"We're dealing with kids in high school, and we've got people retirement age selling," KCSO Sgt. Chris Bryant said. "Pills are easy to get for kids. We've given several drug education classes to teachers, and the first question is always, 'What are those little blue pills we keep seeing?' Those are Roxies."

Some officials expect the problem will only get worse. Opana, a time-release form of oxymorphone introduced five years ago, and fentanyl, a painkiller 100 times more powerful than morphine, offer a stronger high than the old Oxycontin with an even greater potential for overdosing.

Meanwhile, addicts keep working on ways to crack the new Oxys.

"Any time there's a chemical change, there's somebody out there who can alter the effects of that change," Hamblen County Sheriff Esco Jarnagin said. "I don't think you can stop these people from doing what they're doing. The only thing you can do is try to slow them down."

Addiction's Brain Abnormalities Can Be Reversed

 

 

Researchers from the University of Minho in Portugal have discovered that rats exposed before birth to glucocorticoids (GC) not only show several brain abnormalities similar to those found in addicts, but become themselves susceptible to addiction (the glucorticoids, which are stress hormones, were used to mimic pre-natal stress).  But even more remarkable, Ana João Rodrigues, Nuno Sousa and colleagues were able to reverse all the abnormalities  (including the addictive behavior) by giving the animals dopamine (a neurotransmitter/ brain chemical).  The study has several implications – for a start it alerts for the dangers of high levels of stress during pregnancy, but - since GC are often prescribed as an anti-inflammatory or to help organ maturation during pregnancy - it also calls for an urgent investigation on the effects of this drug in pregnant women. But it is what we learn about addiction that is most interesting - the work not only unveils stress as a new susceptibility factor for the disease, but  also a very simple treatment that, if translated into humans, could one day mean an effective treatment, and maybe even the prevention of human addiction.  Drug addiction was for a long time a character flaw, a moral problem. Now, instead,  is accepted as the complex brain disease that is with the addict a patient in need of treatment. After all many people try drugs, but only a few become addicts And it is in these few that lays the key to the disease and its treatment. So what do we know about these patients and the disease? First although the psychological and social contexts in which the drug is taken are important,  as much as 50% of the compulsion is in the  individual’s genetic makeup. We know that addiction is linked to the mesolimbic system - the brain area that evolved to provide feelings of pleasure to actions that increase our survival chances, such as eat, sex and social stimulation. In fact, drugs activate the mesolimbic circuit too, only far stronger than any physiologic stimulus.  This leads to the production of very high quantities of dopamine – the brain chemical linked to pleasure – creating the euphoria that brings users back. After while, though, the brain no longer can cope with the constant ” high” and adapts by becoming desensitised to dopamine (produced by any type of stimulus) what leads users to consume more in order to “feel” again and trapping those more susceptible in addiction. And with the brain changes induced by drugs being apparently long-lasting - since both cravings and relapses don’t disappear with time – it is not easy to escape once trapped. Adding another piece to the puzzle, recently the disease was also linked to stress during crucial developmental periods, such as feotal life. In fact, high levels of prenatal stress increase propensity to mental problems and now have been suggested also to substance abuse, with the effects being mediated by glucocorticoids (GC).    Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 Rodrigues and Sousa’s group have a long history of interest in stress and have seen before that  rats from mothers injected with GC while pregnant (mimicking pre-natal stress) show changes in their mesolimbic area and in the dopamine response. So in the study now published, following these results and the addiction-stress link, the researchers investigated the responses to drugs in rats exposed to GC while in the uterus. These rats were found to have a susceptibility to addiction not present in control (non-exposed) rats. When their mesolimbic system was examined they also showed several structural and molecular abnormalities,  including less dopamine. The levels of their dopamine receptor Drd2, despite initially being very high, once they experimented drugs, went to abnormally low levels . So why is this important? Because reduced dopamine and Drd2 levels are typical of addicts suggesting that stress and long-term exposure to drugs affect the brain in very similar ways what could explain why the first could lead to the second.  Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 The good news is that low levels of dopamine can be treated so Rodrigues and colleagues restored the rats’ dopamine levels to normal just to find,much to their surprise, that all the structural and molecular abnormalities induced by prenatal GC were reversed. Even more surprising, the addictive behavior also disappeared. Normal 0 false false false EN-GB X-NONE X-NONE MicrosoftInternetExplorer4 As Ana João Rodrigues explains, “This is a remarkable result because it suggests that with a relatively simple pharmacological approach- restoration of dopamine levels- we can eventually treat, and even more importantly, potentially prevent drug abuse in vulnerable individuals. Of course that we still have a long way to go but our results are quite promising. In fact, if we know where susceptibility to substance abuse lies – and low dopamine and altered Drd2 response seems to be it - then maybe we can find better ways to prevent/treat this disorder. “ Restoring dopamine levels has been used to treat cocaine cravings but the few trials looking at its effect on addiction were never very clear. One possible reason might be the length or the dosages used – in Rodrigues’ study, rats treated for 3 days reverted back to an addictive behavior 3 weeks after the end of the treatment,  but this no longer occurs if the treatment continues for 3 weeks Now it will be necessary to test this new theory in humans what could be problematic with addicts as they are notoriously not the most cooperative or reliable research subjects. Large human studies on the effect of prenatal stress are also difficult to mount but there are a couple of them being run at the moment that could be tagged into such as “Project Ice Storm” in Canada.This study is following women pregnant n January 98 in southern Québec during an extreme ice storm that led to electrical power failures affecting more than 3 million people for as much as 6 weeks during the coldest month of the year(when temperatures can go to -18 C).  It is still early for any studies on addiction(the children are only 13 years old after all) but it will be an interesting place to look, especially since abnormal levels of behavioral and cognitive problems have already been detected by scientists. Drug abuse and addiction carry enormous social and financial costs to society, families and individuals.Only in the US, the National Institute for Drug Abuse calculates that more than600 billion dollars are being spent, annually, to combat the disease. Despite this,a steady increase of drug use among teenagers and in prescription drugs continues with treatments remaining as inefficient as ever.  Rodrigues and Sousa’s work might be the first step towards a solution if their remarkable results can be translated into humans.

Drug That Killed Michael Jackson "Was Self-Injected"

 

The jury hear evidence that MJ had also taken a large number of sleeping pills… 08:42, Sunday, 30 October 2011 The last defence witness in the trial of Dr Conrad Murray, Michael Jackson’s personal physician, has told the courtroom that he believed the star was responsible for his own death.   Dr Paul White told jurors that the most likely cause of death was self-injection of a fatal dose of the anesthetic Propofol, after Murray had already administered a small amount. "With the administration of the additional 25 milligrams that we're speculating was self-injected by Mr Jackson, the level increases rapidly and at the time of death would be almost identical to the level found in the urine at autopsy," Dr White said. He revealed that the superstar also appeared to have taken a large dose of sedatives – eight Lorazepam tablets – earlier in the night without Murray’s knowledge. White said that mixing the two drugs would be deadly. "The combination effect is potentially profound." Earlier this week a specialist testified that Michael may have also been addicted to the painkiller Demerol, and was also a regular user of Botox. Murray is charged with involuntary manslaughter into the star’s untimely death in June 2009. The prosecution has already presented four weeks of evidence so it won’t be long before the jurors retire to decide the verdict. Michael’s sister Janet Jackson recently postponed tour dates in Australia in order to be in LA when the verdict is announced. She explained her decision in a statement: "When I planned these shows, the schedule in California was completely different. After talking with my family last night, I decided we must be together right now.”

Claus Mogensen 45 years old is a chronic drug addict who lives in Arhus,Denmark.

Clause takes a nap at his room to cool down his system.

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Deadly Drug Overdose Leads to Pill-Pushing Doctor

 

Montgomery County doctor and his son surrendered to police Thursday morning after investigators discovered that they were supplying known drug addicts with large supplies of narcotics, according to authorities. At least one person died of an overdose on Dr. Richard Ruth's drugs, police say. Ruth, of Souderton, was performing insincere medical exams for drug seekers and then providing them with prescription drugs that often ended up being sold in large quantities on the street, police say. Ruth has been running this drug operation for years, authorities say. The lengthy police investigation into Ruth's alleged crimes was called "Operation Pill Pusher." "We know that this community has been plagued by prescription drug abuse and overdoses and this was the go-to guy in the community," said District Attorney Risa Vetri Ferman. Ruth’s son, Michael Ruth, was his medical assistant. "For them to come in and say he’s unlawfully doing things is just an atrocity," a teary-eyed Michael told NBC Philadelphia’s Denise Nakano. Michael also faces charges in the drug scheme that involved charging patients for the narcotic prescriptions and insurance companies for the bogus office visits, police say. Police were tipped off to Dr. Ruth’s drug dealing scheme when sources told them last September that they were able to obtain large amounts of oxycodone from the doctor. In addition to providing drugs to people who dealt them on the street, Dr. Ruth ignored pleas from family members of the drug-addicted patients who asked him to stop prescribing drugs like Percocet and Oxycodone, police say. Dr. Ruth was charged with more than 40 counts of fraud, knowingly prescribing to drug addicts, prescription fraud, and conspiracy, among others. His son Michael was charged with similar crimes.

Is it possible to effectively treat addiction without addressing the spiritual aspects of the problem

The public struggles of celebrities like the late Amy Winehouse reveal how insensitive our society has become to drug and alcohol abuse. But the problem is real, says therapist LaTonya Mason Summers, and we need to reject the ugly trend of laughing at its destructive effects.

LOST SOUL: Amy Winehouse in London on July 23, 2009, exactly two years before her death. (Photo by Shaun Curry/Newscom.)

This week, Amy Winehouse’s official cause of death was finally announced, three months after the singer was discovered dead in her London home on July 23. After initial autopsy results came back inconclusive, the coroner determined that Winehouse died from consuming an extreme amount of alcohol. According to test results, the 27-year-old singer’s blood alcohol level was five times the drunk-driving limit. Her doctor said the troubled star had resumed drinking in the days prior to her death, after a short-lived period of sobriety.

Besides being a talented artist, Winehouse was emblematic of the numerous celebrities today whose public battles with substance abuse are regularly in the headlines. By the end of her life, Winehouse’s struggles had stretched to the point of becoming fodder for jokes and riddles (“Q: What was Amy Winehouse’s biggest hit? A: Her last one!”). Sadly, our society has grown so accustom to addiction that we now laugh it off. But for those in its grips, it’s no joke.

We asked LaTonya Mason Summers, a Charlotte, North Carolina-based mental health therapist, to comment on the realities of drug and alcohol addiction and what we can do to help those affected by it.

UrbanFaith: After Amy Winehouse’s death, the Huffington Post featured a commentary by Rabbi Shais Taub which asked the question, “Was the World Powerless to Stop Amy Winehouse?” In other words, are there addictions so strong and pervasive that they’re beyond human understanding and control? How would you answer that?

LaTonya Mason Summers: The word choice is interesting here, and I agree: the “world” was powerless to stop Amy Winehouse. But it was the “world” that fueled Winehouse’s addictions. Not “world” in the sense of the “earth,” but “world” as defined by Winehouse’s frame of reference — the background, culture, and lifestyle out of which she lived. Addictions are strong, pervasive and hard to understand and control, but it’s even more difficult when one tries to stop addiction by their own strength and understanding. It is reported that Winehouse died from alcohol poisoning. Drug and alcohol abuse is a byproduct of something far deeper. Oftentimes, it’s a symptom of low self-esteem, unresolved trauma and abuse, rejection and abandonment, and mostly fear. We do a great disservice to addicted persons when we focus on their addictions and ignore the underlying problems.

We see so many celebrity drug and alcohol addicts today that our culture has almost grown cold and callous to it. For instance, before her death there was a website devoted solely to the question of “When will Amy Winehouse die?” We see celebrities such as Winehouse, Lindsay Lohan, Whitney Houston, and Charlie Sheen, and we make jokes about them. How does this affect our culture’s understanding of addiction?

When we have a culture entertained by reality TV shows, court and crime TV, and sensationalized Web broadcasting — not to mention today’s popular music — we can’t help but have a desensitized society. We are no longer afraid of or empathetic toward anyone or anything because we’ve been there and done that through TV and the media. So, why wouldn’t we have a “When will Amy Winehouse Die?” website?

Unfortunately, we live in a society that “dumbs down” addictions but tacitly gives a “thumbs up” to its portrayals. Remember when there used to be cautionary documentaries on drugs and alcohol, and on people who struggled with them? Now, we have reality shows that glorify dysfunctional behavior. No wonder we are ignorant. Understanding addictions is no longer newsworthy.

How do you counsel a person with a serious drug addiction? Where do you begin, and what kinds of things should family and friends understand as they’re trying to help that person?

I used to set up and run treatment programs for adolescent and adult substance abusers. I absolutely loved that line of work, but it was emotionally tough. After 11 years of doing it, I stepped away to work solely with mentally ill people. The public sees addicted persons as weak people who lack self-control and deserve every consequence they face. But can you imagine the level of shame, guilt, frustration, and hopelessness that those substance abusers felt by the time they got to me? Imagine having failed everyone, including yourself, family, friends, employers, and the legal system — not to mention God. I always started treatment by instilling hope and restoring the addicted person’s sense of worth. It was much easier to establish rapport, trust, and motivation that way.

God forbid I say this, but oftentimes the families were more sick than the addicts. In fact, family members would wind up on my couch before the addict would. Family work is important in substance-abuse treatment, because the family members can make recovery hard. They help too much. Their helping sometimes hurts the addict. When my patients had toxic families, I’d send my patient to a treatment program in another city or state so they could get better.

Over the summer, former NBA star Jalen Rose was sentenced to 20 days in jail for drunk driving. Some wondered if the treatment was overly harsh because he was a black celebrity, since others have gotten off easier. Do you think jail time is an effective way to steer people clear of destructive behavior involving alcohol and drugs?

In my experience working in the court system as an advocate for my clients, the courts made it worse. The punishment given rarely fit the crime. The probation officers were inconsistent. The judges sent mixed messages by punishing minor crimes with maximum sentences and vice versa. Jail time is punitive, and punishment does not work when the drug or alcohol use is secondary to something else. Addicts don’t mind punishment because they typically feel useless and worthless anyway. That kind of punishment affirms what they believe about themselves. However, I am not saying they should not suffer consequences for drunk driving, drug use, etc. I am saying that offering them rehab while they’re incarcerated might yield greater results.

What kinds of miracles have you seen in your work with people battling addictions?

LaTonya Mason Summers

Goodness, the stories I can tell. I’ve had a hand in imparting into the lives of addicted persons who are now pastors, business owners, and even addictions counselors. I had a 15-year-old girl whose parents brought her to me as a last resort. She had refused other counselors, and I assumed she would do the same with me. After I asked her parents to leave, the girl opened up to me like a book. (It wasn’t because of anything special that I said to her, but other professionals simply had failed to remove the parents.) The girl was a cocaine user and held me by her confidentiality rights, so I could not tell her parents. We made a pact that if she stopped using I would keep her secret. I cannot tell you the anxiety I had for weeks thinking something would go wrong. I collaborated with her physician to drug test her weekly to ensure the girl’s abstinence. After three months, her parents called thanking me for my help. The girl had returned to a healthy weight, her appetite had been restored, and her mood had improved. Today (four years later) she is a successful college student studying psychology.

Among the celebrity success stories that stand out are Robert Downey Jr.’s eventual victory over substance abuse. It only came after several stints in jail and a long, public battle. What kinds of things contribute to a successful road to recovery, and when do you know that someone is legitimately recovered?

My biggest weapon is instilling hope. I do this by challenging the addicted person’s mentality and perspective. I am a cognitive behaviorist, which means I help change the way people think. I do not know what works, as I have often thrown up my hands on clients who later recovered. Then I have lost clients whom I thought had arrived. All I really know is, pray hard in each session. I ask for God’s help. I ask Him to give me the words to say, and I hold on toIsaiah 50:1-7, believing I am called as a therapist.

I honestly don’t know when a person is legitimately recovered, as I believe it’s a lifelong process. Like those of us who are not addicted, we have our own lifelong battles — we try to stop lying, cheating, stealing, yelling, cursing, overeating — everyone has a Goliath they must face. And can any of us say we’ll ever arrive in this world? From my perspective, messing up is just as much part of the recovery process as getting it right is. And, if you get it right all the time, how do you know you’re recovered?

Is it possible to effectively treat addiction without addressing the spiritual aspects of the problem? 

Absolutely not! I’ve had to learn how to minister without saying “God” and “Jesus,” so that I can reach everyone. However, I know how to make others want what I have. I was mentored by a man who told me, “I may not be able to make a horse drink the water, but I should be able to make him thirsty.” And that’s the approach I take in therapy. I see myself as sowing seeds, believing someone will come behind me and water them, and eventually increase will come.

Addiction is spiritual. I believe an addict’s zealousness can be indicative of the great calling on his life. He just needs to move that zealousness away from destructive behavior to purposeful, life-giving behavior.