new study published in the journal Science offers new insight into the mechanism behind cocaine’s addictiveness.

15:05 new study published in the journal Science offers new insight into the mechanism behind cocaine’s addictiveness. 0 Comments

new study published in the journal Science offers new insight into the mechanism behind cocaine’s addictiveness. The research, funded by the National Institute on Drug Abuse (NIDA), points to an epigenetic mechanism of the brain to explain cocaine's addictive effect. Epigenetics is a fairly new avenue of scientific research which looks at changes to gene expression. Such changes are believed to be triggered by environmental factors, such as diet, drugs and toxins.

In the study, researchers at the Mount Sinai School of Medicine gave a group of mice repeated doses of cocaine. Another group receieved saline doses with a final dose of cocaine. The intent was to see how the effects of repeated exposure to cocaine differs from one-time exposure. The researchers found that cocaine alters pleasure circuits in the brain by repressing the G9A enzyme, an important regulator of epigenetic control of gene expression. When the researchers reversed the effect, they were able to block the changes in gene expression and prevent the urge for cocaine.

Researchers hope the discovery may lead to more effective cures for cocaine addiction and perhaps even other substances.